![]() When plasma is allowed to clot, fibrinogen converts to fibrin, trapping the cellular elements of blood. Coagulation inhibitor proteins help to prevent abnormal coagulation (hypercoagulability) and to resolve clots after they are formed. When blood clotting is activated, fibrinogen circulating in the blood is converted to fibrin, which in turn helps to form a stable blood clot at the site of vascular disruption. One critical group is the coagulation proteins and their inhibitors, synthesized primarily in the liver. Learn how scientists used a fidget spinner to separate plasma from blood cells See all videos for this article
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